Mushroom Research Library

Mushroom Research Database for Scientists, Clinicians & Care-Givers.

Published Works

Mushroom Research Institute

Date of Publication: July 2017

Keywords:  Psilocybin; addiction; anxiety; cancer; depression; psychedelic.

Article Name: Potential Therapeutic Effects of Psilocybin

Description: Here, we review therapeutic research on psilocybin, the classic psychedelic that has been the focus of most recent research. For mood and anxiety disorders, three controlled trials have suggested that psilocybin may decrease symptoms of depression and anxiety in the context of cancer-related psychiatric distress for at least 6 months following a single acute administration.

Mushroom Research Institute

Date: February 2001

Keywords: LSD; MDMA; hallucinogens; ketamine; Psilocybin; psychedelics.

Article Name: Clinical Studies on LSD, Psilocybin, MDMA, and Ketamine

Description: In this review, the pharmacology of hallucinogenic compounds is summarized by underscoring the differences between psychedelic and nonpsychedelic hallucinogens as well as entactogens, and their behavioral effects in both animals and humans are described.

Mushroom Research Institute

Date: May 2021

Keywords:   addiction; anxiety; cancer; depression; magic mushrooms; neuropharmaceuticals; neurotherapeutics; Psilocybin; psychedelic; psychopharmacology.

Article Name: The Therapeutic Potential of Psilocybin

Description: This review will explore the potential of psilocybin in the treatment of neuropsychiatry-related conditions, examining recent advances as well as current research.

Mushroom Research Institute

Date: May 2016

Keywords:   depression; magic mushrooms; neuropharmaceuticals; neurotherapeutics; Psilocybin; psychedelic; psychopharmacology. 

Article Name: Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study

Description: This study provides preliminary support for the safety and efficacy of psilocybin for treatment-resistant depression and motivates further trials, with more rigorous designs, to better examine the therapeutic potential of this approach.

Mushroom Research Institute

Date: November 2017

Keywords:   Serotonin, 5-HT2AR, Depression, Treatment-resistant depression, Psilocybin, Psychedelic, Mood, Hallucinogen, Psychotherapy

Article Name: Psilocybin with psychological support for treatment-resistant depression: six-month follow-up

Description: This review will explore the potential of psilocybin in the treatment of neuropsychiatry-related conditions, examining recent advances as well as current research.

Mushroom Research Institute

Date: December 2016

Keywords:   Psilocybin, anxiety, cancer, depression, hallucinogen, mystical experience, symptom remission 

Article Name: Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial

Description: This randomized, double-blind, cross-over trial investigated the effects of a very low (placebo-like) dose (1 or 3 mg/70 kg) vs. a high dose (22 or 30 mg/70 kg) of psilocybin administered in counterbalanced sequence with 5 weeks between sessions and a 6-month follow-up.

Mushroom Research Institute

Date: October 2017

Keywords:   Psilocybin, treatment-resistant depression, fMRI 

Article Name: Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms

Description:  Here, cerebral blood flow (CBF) and blood oxygen-level dependent (BOLD) resting-state functional connectivity (RSFC) were measured with functional magnetic resonance imaging (fMRI) before and after treatment with psilocybin (serotonin agonist) for treatment-resistant depression (TRD).

Mushroom Research Institute

Date: December 2016

Keywords:   Psilocybin, anxiety, cancer, depression, mystical experience, psychedelic 

Article Name: Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial.

Description: In this double-blind, placebo-controlled, crossover trial, 29 patients with cancer-related anxiety and depression were randomly assigned and received treatment with single-dose psilocybin (0.3 mg/kg) or niacin, both in conjunction with psychotherapy. The primary outcomes were anxiety and depression assessed between groups prior to the crossover at 7 weeks.

Mushroom Research Institute

Date: May 2021

Keywords:   psilocybin-Assisted Therapy, psilocybin, major depressive disorder, mdd, psychedelic integration therapy, p.i.t., p.a.t.

Article Name: Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder: 

Description: In this randomized clinical trial of 24 participants with major depressive disorder, participants who received immediate psilocybin-assisted therapy compared with delayed treatment showed improvement in blinded clinician rater–assessed depression severity and in self-reported secondary outcomes through the 1-month follow-up

Mushroom Research Institute

Date: date

Keywords:    Hallucinogen, addiction, mystical experience, nicotine, psilocybin, psychedelic, smoking cessation,spirituality,tobacco

Article Name: Long-term follow-up of psilocybin-facilitated smoking cessation

Description: To assess long-term effects of a psilocybin-facilitated smoking cessation program at ≥12 months after psilocybin administration.

Mushroom Research Institute

Date: September 2020

Keywords:   anxiety, clinical trials, depression, meta-analysis, psilocybin, systematic review

Article Name: Psilocybin in the Context of Life-Threatening Diseases

Description: The aim of this work was to perform a systematic review with meta-analysis of clinical trials to assess the therapeutic effects and safety of psilocybin on those medical conditions.

Mushroom Research Institute

Date: September 2021

Keywords:   antidepressant therapy, depression, psilocin, psilocybin, review,

Article Name: Rediscovering Psilocybin as an Antidepressive Treatment Strategy

Description:  With this review, we provide an overview of the current state of research on the potential mechanisms of psilocybin, its antidepressant potential, and the associated risks and adverse effects, to provide an update on a controversial topic discussed in psychopharmacology.

Mushroom Research Institute

Date: November 2018

Keywords:  depression, personality, NEO‐PI‐R, Openness, psilocybin, psychedelic

Article Name: Effects of psilocybin therapy on personality structure

Description: Twenty patients with moderate or severe, unipolar, TRD received oral psilocybin (10 and 25 mg, one week apart) in a supportive setting. Personality was assessed at baseline and at 3‐month follow‐up using the Revised NEO Personality Inventory (NEO‐PI‐R), the subjective psilocybin experience with Altered State of Consciousness (ASC) scale, and depressive symptoms with QIDS‐SR16.

Mushroom Research Institute

Date: November 2018

Keywords:   amygdala, depression, emotional processing, psilocybin, psychedelics, fMRI,

Article Name: Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression

Description: In this open-label study, 20 individuals diagnosed with moderate to severe, treatment-resistant depression, underwent two separate dosing sessions with psilocybin. Psychological support was provided before, during and after these sessions and 19 completed fMRI scans one week prior to the first session and one day after the second and last.

Mushroom Research Institute

Date: January 2021

Keywords:   Functional connectivity,Serotonin,Dopamine,Resting-state,Mouse,

Article Name: Psilocybin exerts distinct effects on resting state networks associated with serotonin and dopamine

Description: In this study, we investigated the effects of psilocybin on FC across the entire brain with a view to investigate underlying mechanisms. 

Mushroom Research Institute

Date: November 2018

Keywords:  psilocybin, abuse potential, Controlled Substances Act, depression, anxiety, addiction

Article Name: The Abuse Potential of Medical Psilocybin According to 8 Factors of the Controlled Substances Act

Description: This review assesses the abuse potential of medically-administered psilocybin, following the structure of the 8 factors of the US Controlled Substances Act (CSA). 

Mushroom Research Institute

Date: June 2017

Keywords:   empathy, moral decision-making, psilocybin, serotonin, 5-HT2A/1A receptors

Article Name: Effect of Psilocybin on Empathy and Moral Decision-Making

Description: We investigated the acute effect of psilocybin (0.215 mg/kg p.o.) in healthy human subjects on different facets of empathy and hypothetical moral decision-making using the multifaceted empathy test (n=32) and the moral dilemma task (n=24).

Mushroom Research Institute

Date: April 2021

Keywords:   depression, hallucination, hallucinogen, psychedelic, serotonin

Article Name: Antidepressant-like actions of psilocybin are independent of 5-HT2R activation in mice

Description: We therefore asked whether psilocybin would exert antidepressant-like responses in mice and, if so, whether these responses required 5-HT2AR activation. 

Mushroom Research Institute

Date: February 2021

Keywords:  anxiety, depression, obsessive-compulsive disorder, psilocybin, substance-related disorders

Article Name: What is the clinical evidence on psilocybin for the treatment of psychiatric disorders? A review.

Description: In this paper we performed a systematic review of the clinical trials conducted so far regarding the therapeutic effects of psilocybin on psychiatric disorders.

Mushroom Research Institute

Date: JUNE 2019

Keywords:  medical research, target validation, drug development, emotion

Article Name: Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels

Description: We here report for the first time the relationship between intensity of psychedelic effects, cerebral 5-HT2AR occupancy and plasma levels of psilocin in humans. 

Mushroom Research Institute

Date: March 2020

Keywords:   depression, mindfulness meditation, psilocybin, psychedelics, review

Article Name: Possible Complementary Effects of Mindfulness Meditation and and Psilocybin in the Treatment of Depression

Description: Based on predefined search strings used in two online databases (PubMed and Google Scholar) 1129 articles were identified. After screening title and abstract for relevance related to the question, 82 articles were retained and 11 were added after reference list search, resulting in 93 articles included in the review. Findings show that MM and psilocybin exert similar effects on mood, social skills, and neuroplasticity; different effects were found on executive functioning, neural core networks, and neuroendocrine and neuroimmune system markers.

Mushroom Research Institute

Date: September 2020

Keywords:   Psychedelics, Resting state, Serotonin 2A receptor, fMRI.

Article Name: Psilocybin acutely alters the functional connectivity of the claustrum with brain networks that support perception, memory, and attention

Description: We tested the hypothesis that psilocybin modulates claustrum function in humans.

Mushroom Research Institute

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Mushroom Research Institute

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Mushroom Research Institute

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