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  • Psilocybin with psychological support for treatment-resistant depression: six-month follow-up

    Relative to baseline, marked reductions in depressive symptoms were observed for the first 5 weeks post-treatment (Cohen's d = 2.2 at week 1 and 2.3 at week 5, both p < 0.001); nine and four patients met the criteria for response and remission at week 5. No patients sought conventional antidepressant treatment within 5 weeks of psilocybin. Reductions in depressive symptoms at 5 weeks were predicted by the quality of the acute psychedelic experience

  • Antidepressant-like actions of psilocybin are independent of 5-HT2R activation in mice

    HT2AR) activation. HT2AR activation. HT2A/2C antagonist ketanserin, despite positive evidence of ketanserin's efficacy. We further suggest that a 5-HT2AR-independent restoration of synaptic strength in cortico-mesolimbic The possibility of combining psychedelic compounds and a 5-HT2AR antagonist offers a potential means

  • Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin

    Psychedelic effects are believed to emerge through stimulation of serotonin 2A receptors (5-HT2ARs) by Eight healthy volunteers underwent positron emission tomography (PET) scans with the 5-HT2AR agonist HT2AR occupancy was calculated as the percent change in cerebral 5-HT2AR binding relative to baseline Psilocybin intake resulted in dose-related 5-HT2AR occupancies up to 72%; plasma psilocin levels and 5-HT2AR occupancy conformed to a single-site binding model.

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  • ZenSpore | Unites States | Mushroom Research Library

    Mushroom Research Library A Mushroom Research Database for Scientists, Clinicians & Care-Givers. 5-HT2AR Mushroom Research Institute Date: November 2017 Keywords: Serotonin, 5-HT2AR, Depression, Treatment-resistant HT2A/1A receptors Article Name: Effect of Psilocybin on Empathy and Moral Decision-Making Description responses in mice and, if so, whether these responses required 5-HT2AR activation. HT2AR occupancy and plasma levels of psilocin in humans.

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