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  • Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression

    We hypothesised that amygdala responses to emotional faces would be altered post-treatment with psilocybin Psilocybin with psychological support was associated with increased amygdala responses to emotional stimuli suggests fundamental differences in these treatments’ therapeutic actions, with SSRIs mitigating negative emotions propose that psilocybin with psychological support is a treatment approach that potentially revives emotional responsiveness in depression, enabling patients to reconnect with their emotions.

  • Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin

    June 2019 ABSTRACT The main psychedelic component of magic mushrooms is psilocybin, which shows promise as a treatment for depression and other mental disorders. Psychedelic effects are believed to emerge through stimulation of serotonin 2A receptors (5-HT2ARs) by psilocybin’s active metabolite, psilocin. We here report for the first time the relationship between intensity of psychedelic effects, cerebral 5-HT2AR occupancy and plasma levels of psilocin in humans. Eight healthy volunteers underwent positron emission tomography (PET) scans with the 5-HT2AR agonist radioligand [11C]Cimbi-36: one at baseline and one or two additional scans on the same day after a single oral intake of psilocybin (3–30 mg). 5-HT2AR occupancy was calculated as the percent change in cerebral 5-HT2AR binding relative to baseline. Subjective psychedelic intensity and plasma psilocin levels were measured during the scans. Relations between subjective intensity, 5-HT2AR occupancy, and plasma psilocin levels were modeled using non-linear regression. Psilocybin intake resulted in dose-related 5-HT2AR occupancies up to 72%; plasma psilocin levels and 5-HT2AR occupancy conformed to a single-site binding model. Subjective intensity was correlated with both 5-HT2AR occupancy and psilocin levels as well as questionnaire scores. We report for the first time that intake of psilocybin leads to significant 5-HT2AR occupancy in the human brain, and that both psilocin plasma levels and 5-HT2AR occupancy are closely associated with subjective intensity ratings, strongly supporting that stimulation of 5-HT2AR is a key determinant for the psychedelic experience. Important for clinical studies, psilocin time-concentration curves varied but psilocin levels were closely associated with psychedelic experience. [FULL TEXT]

  • Effect of Psilocybin on Empathy and Moral Decision-Making

    Results Psilocybin significantly increased emotional, but not cognitive empathy compared with placebo , and the increase in implicit emotional empathy was significantly associated with psilocybin-induced findings provide first evidence that psilocybin has distinct effects on social cognition by enhancing emotional Furthermore, together with previous findings, psilocybin appears to promote emotional empathy presumably

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  • ZenSpore | Unites States | Mushroom Research Library

    Mushroom Research Institute Date: November 2018 Keywords: amygdala, depression, emotional processing, psilocybin, psychedelics, fMRI, Article Name: Increased amygdala responses to emotional faces after Research Institute Date: JUNE 2019 Keywords: m edical research, target validation, drug development, emotion

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