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  • Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin

    June 2019 ABSTRACT The main psychedelic component of magic mushrooms is psilocybin, which shows promise Psychedelic effects are believed to emerge through stimulation of serotonin 2A receptors (5-HT2ARs) by We here report for the first time the relationship between intensity of psychedelic effects, cerebral Subjective psychedelic intensity and plasma psilocin levels were measured during the scans. studies, psilocin time-concentration curves varied but psilocin levels were closely associated with psychedelic

  • Rapid and sustained symptom reduction following psilocybin treatment

    Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Background: Clinically significant anxiety and depression are common in patients with cancer, and are associated with poor psychiatric and medical outcomes. Historical and recent research suggests a role for psilocybin to treat cancer-related anxiety and depression. Methods: In this double-blind, placebo-controlled, crossover trial, 29 patients with cancer-related anxiety and depression were randomly assigned and received treatment with single-dose psilocybin (0.3 mg/kg) or niacin, both in conjunction with psychotherapy. The primary outcomes were anxiety and depression assessed between groups prior to the crossover at 7 weeks. Results: Prior to the crossover, psilocybin produced immediate, substantial, and sustained improvements in anxiety and depression and led to decreases in cancer-related demoralization and hopelessness, improved spiritual wellbeing, and increased quality of life. At the 6.5-month follow-up, psilocybin was associated with enduring anxiolytic and anti-depressant effects (approximately 60-80% of participants continued with clinically significant reductions in depression or anxiety), sustained benefits in existential distress and quality of life, as well as improved attitudes towards death. The psilocybin-induced mystical experience mediated the therapeutic effect of psilocybin on anxiety and depression. Conclusions: In conjunction with psychotherapy, single moderate-dose psilocybin produced rapid, robust and enduring anxiolytic and anti-depressant effects in patients with cancer-related psychological distress. Trial registration: Identifier: NCT00957359. [FULL TEXT]

  • Potential therapeutic effects of Psilocybin

    October 2017 Psilocybin and other 5-hydroxytryptamine2A agonist classic psychedelics have been used for By the late 1960s and early 1970s these scientific inquires fell out of favor because classic psychedelics However, in the twenty-first century, scientific interest in classic psychedelics has returned and grown Here, we review therapeutic research on psilocybin, the classic psychedelic that has been the focus of

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  • ZenSpore | Unites States | Mushroom Research Library

    Institute Date of Publication: July 2017 Keywords: Psilocybin; addiction; anxiety; cancer; depression; psychedelic Effects of Psilocybin Description: Here, we review therapeutic research on psilocybin, the classic psychedelic the pharmacology of hallucinogenic compounds is summarized by underscoring the differences between psychedelic anxiety; cancer; depression; magic mushrooms; neuropharmaceuticals; neurotherapeutics; Psilocybin; psychedelic Mushroom Research Institute Date: September 2020 Keywords: Psychedelics, Resting state, Serotonin 2A

  • New York, NY | ZenSpore

    Field Trip Health For Psychadelic Therapy The Reuben Museum High Zen Birds Seed Company New York, NY.

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